MediaPharma S.r.l.
A Company focused on the discovery and development of innovative drugs for the treatment of cancer and other diseases with unmet medical need.

Archivi del mese: novembre 2013


TEM-1/ Endosialin Antibody-Drug Conjugate

The TEM-1/Endosialin/CD248 receptor is expressed in the cell surface of tumor-associated stroma cells, as well as in sarcoma and neuroblastoma cells. This receptor is emerging as an attractive molecule in diagnostics and therapeutics because of its expression across the stroma of many human tumors, the low to absent expression in normal tissues and accessibility from the vascular circulation.

MediaPharma’s scientists have generated a novel anti-TEM-1 Antibody-Drug Conjugate (TEM-1-ADC). It consists of a humanized anti-TEM-1 monoclonal antibody (E.8-3) conjugated to a highly potent duocarmycin derivative by means of a linker. In TEM-1 expressing cancer cell lines, this TEM-1-ADC shows a powerful, specific and target-dependent killing activity. Aministration of  TEM-1-ADC was effective in inducing a long lasting tumor growth inhibition of cell line-based models of human sarcoma.

Indications in oncology:

Sarcoma, melanoma, neuroblastoma, colorectal carcinoma




EV20 labeled with 89Zr

Preclinical proof of activity established: in vivo localization of HER3+ human tumor xenografts.

Indications in Oncology
In vivo localization of HER3-expressing cancer by immuno-PET.