The company is focused on the discovery, development and commercialization of monoclonal antibodies
Cancer drug companies
Anti-cancer drug investigations
The NCI played an early role in the development of anti-cancer drugs in the U.S. According to a 1996 NCI analysis of drugs approved by the FDA, two-thirds of the anti-cancer drugs approved as of the end of 1995 were NCI-sponsored Investigational New Drugs:
Alkylating agents
Cyclophosphamide.
.
Chlorambucil (Leukeran) (1957)
Cyclophosphamide (Cytoxan) (1959)
Thiotepa (1959)
Melphalan (Alkeran) (1959) (IV in 1993)
Streptozotocin (Zanosar) (1982)
Ifosfamide (Ifex) (1988)
Antimetabolites
Mercaptopurine (1953)
Methotrexate (1953)
Thioguanine (1966)
Cytosine arabinoside (Ara-C) (1969)
Floxuridine (FUDR) (1970)
Fludarabine phosphate (1991)
Pentostatin (1991)
Chlorodeoxyadenosine (1992)
Plant alkaloids and antibiotics
Vincristine.
Vincristine (Oncovin) (1963)
Actinomycin D (Cosmegen) (1964)
Mithramycin (Mithracin) (1970)
Bleomycin (Blenoxane) (1973)
Doxorubicin (Adriamycin) (1974)
Mitomycin C (Mutamycin) (1974)
L-Asparaginase (Elspar) (1978)
Daunomycin (Cerubidine) (1979)
VP-16-213 (Etoposide) (1983)
VM-26 (Teniposide) (1992)
Taxol (Paclitaxel) (1992)
Synthetic drugs
Carboplatin.
Hydroxyurea (Hydrea) (1967)
Procarbazine (Matulane) (1969)
O, P'-DDD (Lysodren, Mitotane) (1970)
Dacarbazine (DTIC) (1975)
CCNU (Lomustine) (1976)
BCNU (Carmustine) (1977)
Cis-diamminedichloroplatinum (Cisplatin) (1978)
Mitoxantrone (Novantrone) (1988)
Carboplatin (Paraplatin) (1989)
Levamisole (Ergamisol) (1990)
Hexamethylmelamine (Hexalen) (1990)
All-trans retinoid acid (Vesanoid) (1995)
Porfimer sodium (Photofrin) (1995)
Hormones and steroids
DES (1950)
Prednisone (1953)
Fluoxymesterone (Halotestin) (1958)
Dromostanolone (Drolban) (1961)
Testolactone (Teslac) (1970)
Methyl prednisolone
Prednisolone
Zoladex (1989)
Biologicals
Alpha interferon (Intron A, Roferon-A) (1986)
BCG (TheraCys, TICE) (1990)
G-CSF (1991)
GM-CSF (1991)
Interleukin 2 (Proleukin) (1992)
In addition, scientists in the NCI played an important role in the discovery and development of important AIDS drugs including zidovudine (AZT), didanosine (ddI), and zalcitabine (ddC).
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Last updated: 20/07/2009 14:02Tag Cloud
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