The company is focused on the discovery, development and commercialization of monoclonal antibodies
MHC class II
Class II Human Leukocyte Antigens (HLA) are surface molecules expressed by professional antigen-presenting cells (dendritic cells, macrophages, B-lymphocytes and activated T cells), as well as certain normal and neoplastic non- lymphoid cells.
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| Antibody to | Catalogue Number | DATA SHEET | Clone | Unit Size | Antibody form | Host animal | Isotype | Price (€) | Order |
|---|---|---|---|---|---|---|---|---|---|
| Human HLA (MHC) class II |
MP-AA-05.1 |
 |
KUL/05 |
150 µg | Caprylic ac. purified |
Mouse monoclonal | IgG1 | 300,00 |  |
| MP-AA-05.2 | |
KUL/05 |
50 µl | Unpurified reagent | Mouse monoclonal | IgG1 | 200,00 | |
|
| MP-AA-05.3 | |
KUL/05 |
200 µl | Unpurified reagent | Mouse monoclonal | IgG1 | 560,00 | |
|
Datasheet preview
BACKGROUND
Class II Human Leukocyte Antigens (HLA) are surface molecules expressed by professional antigen-presenting cells (dendritic cells, macrophages, B-lymphocytes and activated T cells), as well as certain normal and neoplastic non- lymphoid cells. There are three major allelic series of classical, surface- expressed class II molecules: HLA-DR, HLA-DQ, and HLA-DP, each comprising two polymorphic, glycosylated polypeptide chains (α and β) and associating with distinct sets of small peptide antigens.
PRODUCT
1. Each vial contains the indicated amount of IgG (caprylic acid purified) in 0.1% gelatine and 0.05% NaN3.
2. Unpurified reagent is provided at the indicated amounts with 0.1% NaN3.
Centrifuge the vial prior to use.
SPECIFICITY
The murine monoclonal antibody MM-P-5 (IgG1) recognizes a framework epitope that is (i) shared by the β chains of HLA-DR, -DQ as well as - DP molecules, and (ii) is present on these molecules regardless of their native (surfaceexpressed), or denatured form.
STORAGE
Store frozen, avoid repeated freeze-thawing. Stable for 2 yrs.
SHIPPING CONDITIONS
Room temperature.
RESEARCH USE
This antibody is for laboratory research use only, not for human or in-vivo use.
APPLICATIONS
Flow cytometry, 10-20 µg/ml.
Immunohistochemistry (fluorescence, enzymatic), Acetone-fixed cryostatic sections and cytospins (5 µg/ml). Formalin-fixed, paraffin-embedded sections with no need for antigen retrieval procedures. Under these conditions an overnight incubation was found to provide the most consistent staining patterns (2-5 µg/ml).
Immunoprecipitation, 1 to 5 µg, using rabbit anti-mouse Ig and protein A-sepharose beads.
Western blotting, 1 µg/ml.
Last updated: 21/07/2011 10:10
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