The company is focused on the discovery, development and commercialization of monoclonal antibodies
Human Her 2 neu
Its overexpression characterizes about 25% of breast cancers with unfavourable prognosis candidate to treatment with humanized anti HER-2 targeting therapies.
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| ANTIBODY TO | CATALOGUE NUMBER | DATA SHEET | CLONE | UNIT SIZE | ANTIBODY FORM | HOST ANIMAL | ISOTYPE | PRICE (€) | ORDER |
|---|---|---|---|---|---|---|---|---|---|
| Human Her-2/neu |
MP-AA-02.1 |  |
300G9b | 150 µg | Caprylic ac. purified |
Mouse monoclonal | IgG1 | 350,00 |  |
| MP-AA-02.2 | |
300G9b | 50 µl | Unpurified reagent | Mouse monoclonal | IgG1 | 250,00 | |
|
| MP-AA-02.3 | |
300G9b | 200 µl | Unpurified reagent | Mouse monoclonal | IgG1 | 700,00 | |
Datasheet preview
BACKGROUND
HER-2/neu belongs to the EGFR family of thyrosine kinase receptors. Its overexpression characterizes about 25% of patients with breast cancers candidate to treatment with anti HER-2 targeting therapies.
PRODUCT
1. Each vial contains the indicated amount of IgG (caprylic acid purified) in 0.1% gelatine and 0.05% NaN3.
2. Unpurified reagent is provided at the indicated amounts with 0.1% NaN3.
Centrifuge the vial prior to use.
SPECIFICITY
The murine monoclonal antibody MP-AA-2 (IgG1) has been generated using NHI-3T3 cells transfected with the human receptor (ref.1) It recognizes an epitope of the extracellular domain of the human gp185HER-2/neu resistant to formalin fixation. It recognizes the receptor with an affinity of 2x109M-1. The reagent does not crossreact with non human receptors (see references).
STORAGE
Store at 4° C, avoid repeated freezing-thawing. Stable for one year.
SHIPPING CONDITIONS
Room temperature.
RESEARCH USE
This antibody is for laboratory research use only, not for human or in-vivo use.
APPLICATIONS
Flow cytometry, 5-10 µg/ml
Immunohistochemistry, (fluorescence, enzymatic), On acetone fixed cryostat sections and cytospins (5-10 µg/ml); paraffin embedded tissue sections (enzymatic 20 µg/ml) with no need of antigen retrieving procedures. MP-AA-2 and FISH analysis have been shown over 80% concordance (ref.4)
Immunoprecipitation, 2 µg, using rabbit anti-mouse Ig and protein ASepharose beads (ref.1).
Last updated: 21/07/2011 09:09
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