The company is focused on the discovery, development and commercialization of monoclonal antibodies
Endoglin CD105
Endoglin CD105, a homodimeric transmembrane glycoprotein composed of disulphide-linked subunits of 95 kDa, is the most reliable marker of proliferation of endothelial cells. It is over expressed on tumor neo-vasculature.
To create a purchase order please select your item(s) clicking on the green "+" icone,
then simply follow the ordering steps.
| Antibody to | Catalogue Number | DATA SHEET | Clone | Unit Size | Antibody form | Host animal | Isotype | Price (€) | Order |
|---|---|---|---|---|---|---|---|---|---|
|
Human |
MP-AA-09.1 |  |
MAEND3 | 150 µg | Caprylic ac. purified |
Mouse monoclonal | IgG1 | 300,00 |  |
|
|
MP-AA-09.2 | |
MAEND3 |
50 µl |
Unpurified reagent | Mouse monoclonal | IgG1 | 200,00 | |
| MP-AA-09.3 | |
MAEND3 | 200 µl | Unpurified reagent | Mouse monoclonal | IgG1 | 560,00 | |
|
Datasheet preview
BACKGROUND
Endoglin/CD105, a homodimeric, transmembrane glycoprotein composed of disulphide-linked subunits of 95 kDa. It is the most reliable marker of proliferation of endothelial cells. It is over expressed on tumor neovasculature. The available information indicates Endoglin as a powerful diagnostic and therapeutic target in human malignancies, through the imaging and the inhibition of tumor related angiogenesis.
PRODUCT
1. Each vial contains the indicated amount of IgG (caprylic acid purified) in 0.1% gelatine and 0.05% NaN3.
2. Unpurified reagent is provided at the indicated amounts with 0.1% NaN3.
Centrifuge the vial prior to use.
SPECIFICITY
Mab MAEND3 (IgG1) recognizes native CD105.
STORAGE
Store frozen and avoid repeated freeze-thawing. Stable for 2 yrs.
SHIPPING CONDITIONS
Room temperature.
RESEARCH USE
This antibody is for laboratory research use only, not for human or in-vivo use.
APPLICATIONS
Flow cytometry, 10-20 µg/ml on human umbilical vein endothelial cells (HUVEC) (ref. 1,2,3).
Immunohistochemistry (fluorescence , enzymatic), Acetone-fixed cryostat sections (10-20 µg/ml).
Immunoprecipitation, 5 µg, using rabbit anti-mouse Ig and protein ASepharose beads (ref.1).
Dot Blot Assay for soluble Endoglin, Mab MAEND3 (5 µg/ml) recognizes soluble Endoglin in conditioned medium from HUVEC, various cancer cell lines, and in sera of patients with melanoma and myeloid malignancies (ref. 3,4).
Last updated: 21/07/2011 11:11
MediaPharma s.r.l. P.IVA.: IT 02282760699 | Rea di Chieti: 166532
The information provided on www.mediapharma.it is designed to complement, not replace, the relationship between a patient and his/her own physician.
