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• Monoclonal Antibodies Catalogue

  Provision of high quality monoclonal antibodies

  Updated | 04/10/2011 15:03

• Tenascin C

  Tenascin C (TN-C) is an extracellular matrix glycoprotein with a unique six-armed structure. This glycoprotein modulates reciprocal interactions between epithelia and mesenchima during embryogenesis and contributes to stem cell niches.

  Updated | 21/07/2011 11:11

• Endoglin CD105

  Endoglin CD105, a homodimeric transmembrane glycoprotein composed of disulphide-linked subunits of 95 kDa, is the most reliable marker of proliferation of endothelial cells. It is over expressed on tumor neo-vasculature.

  Updated | 21/07/2011 11:11

• Proteoglycans

  Proteoglycans are cell surface linked macromolecules which through protein modules and glycan moieties modulate numerous cellular interactions during embryogenesis, healthy and pathologic state, including tumor progression and neoangiogenesis.

  Updated | 21/07/2011 10:10

• HLA-C

  Class I Human Leukocyte Antigens (HLA-C ) are heterodimeric (heavy chain + β2m) surface molecules that bind small peptide antigens and engage T lymphocytes and NK cells expressing the T cell receptor and Killer Immunoglobulin- like Receptors (KIR).

  Updated | 21/07/2011 10:10

• TRK A receptor

  TRK A is the high affinity catalytic receptor for the neurotrophin Nerve Growth Factor. Besides mediating neuronal differentiation and survival, it plays a role in the tumorigenesis of nonneural tumors, primarily carcinomas.

  Updated | 21/07/2011 10:10

• MHC class II

  Class II Human Leukocyte Antigens (HLA) are surface molecules expressed by professional antigen-presenting cells (dendritic cells, macrophages, B-lymphocytes and activated T cells), as well as certain normal and neoplastic non- lymphoid cells.

  Updated | 21/07/2011 10:10

• Human Tyrosinase

  The copper containing enzyme tyrosinase, essential to pigmentation in mammals, is specifically synthesized by epithelial and mucosal melanocytes, pigmented epithelium of the ciliary body and retina.

  Updated | 21/07/2011 10:10

• Alpha integrins

  Integrins are cell surface receptors mediating cell to cell and cell to extracellular matrix (ECM) interactions. They exist as non covalently linked alfa and beta subunits heterodimers displaying specificity for one or more ligands.

  Updated | 21/07/2011 09:09

• Human Her 2 neu

  Its overexpression characterizes about 25% of breast cancers with unfavourable prognosis candidate to treatment with humanized anti HER-2 targeting therapies.

  Updated | 21/07/2011 09:09

• Galectin-3

  90K, also known as Mac-2BP or LGALS3BP (lectin, galactoside binding, soluble, 3 binding protein) is a large oligomeric protein that was originally identified as a secreted tumor-associated antigen and as a ligand of galectin-3 (formerly Mac-2). 90K has a role in cell adhesive processes.

  Updated | 21/07/2011 09:09

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The information provided on www.mediapharma.it is designed to complement, not replace, the relationship between a patient and his/her own physician.

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